
| 2002-03 | AMBHL | Knights of Columbus Squires Btm | 36 | 17 | 26 | 43 | 0 | - | - | 8 |
| 2003-04 | AMBHL | Knights of Columbus Squires Btm | 33 | 35 | 26 | 61 | 0 | - | - | 32 |
| 2004-05 | AMHL | K of C Pats | 36 | 15 | 17 | 32 | - | - | - | 10 |
| 2005-06 | WHL | Medicine Hat | 43 | 3 | 7 | 10 | -1 | - | - | 10 |
| 2006-07 | WHL | Medicine Hat | 71 | 26 | 24 | 50 | 1 | - | - | 30 |
| 2007-08 | WHL | Medicine Hat | 70 | 43 | 48 | 91 | 11 | - | - | 42 |
| 2008-09 | WHL | Medicine Hat | 61 | 43 | 42 | 85 | 11 | - | - | 21 |
| 2009-10 | NHL | Buffalo Sabres | 10 | 3 | 6 | 9 | 1 | 23 | 13.0% | 6 |
| 2009-10 | AHL | Portland | 69 | 23 | 42 | 65 | -1 | - | - | 12 |
| 2010-11 | NHL | Buffalo Sabres | 82 | 20 | 29 | 49 | 0 | 210 | 9.5% | 30 |
| 2011-12 | NHL | Buffalo Sabres | 48 | 15 | 19 | 34 | 11 | 82 | 18.3% | 14 |
| 2012-13 | NHL | Buffalo Sabres | 47 | 10 | 21 | 31 | -14 | 108 | 9.3% | 16 |
| 2012-13 | Swiss | Langnau | 9 | 3 | 5 | 8 | - | - | - | 0 |
| 2013-14 | NHL | Buffalo Sabres | 80 | 21 | 22 | 43 | -25 | 210 | 10.0% | 42 |
| 2014-15 | NHL | Buffalo Sabres | 78 | 20 | 26 | 46 | -19 | 185 | 10.8% | 37 |
| 2015-16 | NHL | Buffalo Sabres | 23 | 3 | 8 | 11 | -9 | 57 | 5.3% | 11 |
| 2016-17 | NHL | Buffalo Sabres | 51 | 5 | 8 | 13 | -10 | 89 | 5.6% | 12 |
| 2017-18 | NHL | Minnesota Wild | 73 | 8 | 14 | 22 | -1 | 115 | 7.0% | 12 |
| 2018-19 | NHL | Toronto Maple Leafs | 51 | 12 | 6 | 18 | -6 | 81 | 14.8% | 2 |
| 2019-20 | NHL | Ottawa Senators | 61 | 14 | 19 | 33 | -5 | 139 | 10.1% | 16 |
| 2019-20 | NHL | Edmonton Oilers | 9 | 2 | 2 | 4 | -1 | 20 | 10.0% | 4 |
| 2020-21 | NHL | Edmonton Oilers | 30 | 3 | 6 | 9 | 0 | 38 | 7.9% | 6 |
| 2021-22 | NHL | Ottawa Senators | 57 | 8 | 16 | 24 | -6 | 89 | 9.0% | 16 |
| 2022-23 | NL | Bern | 37 | 13 | 20 | 33 | -6 | - | - | 8 |
| 2023-24 | DEL | Adler Mannheim | 7 | 0 | 5 | 5 | -4 | - | - | 2 |
| 2023-24 | Champions HL | Adler Mannheim | 2 | 0 | 1 | 1 | -3 | - | - | 2 |
| NHL Totals | – | 700 | 144 | 202 | 346 | -84 | 1446 | 10.0% | 224 | |
| AHL Totals | – | 69 | 23 | 42 | 65 | -1 | - | - | 12 | |
| Juniors Totals | – | 245 | 115 | 121 | 236 | 22 | - | - | 103 | |
| 2005-06 | WHL | Medicine Hat | 7 | 0 | 0 | 0 | 0 | - | - | 0 |
| 2006-07 | WHL | Medicine Hat | 22 | 8 | 4 | 12 | 1 | - | - | 6 |
| 2006-07 | M-Cup | Medicine Hat | 4 | 2 | 2 | 4 | - | - | - | 4 |
| 2007-08 | WHL | Medicine Hat | 5 | 0 | 4 | 4 | -2 | - | - | 6 |
| 2008-09 | WHL | Medicine Hat | 11 | 8 | 11 | 19 | -1 | - | - | 10 |
| 2009-10 | NHL | Buffalo Sabres | 6 | 1 | 3 | 4 | 1 | 20 | 5.0% | 0 |
| 2010-11 | NHL | Buffalo Sabres | 7 | 2 | 2 | 4 | 4 | 17 | 11.8% | 4 |
| 2017-18 | NHL | Minnesota Wild | 1 | 0 | 0 | 0 | -1 | 1 | 0.0% | 0 |
| 2018-19 | NHL | Toronto Maple Leafs | 5 | 0 | 2 | 2 | 1 | 5 | 0.0% | 2 |
| 2019-20 | NHL | Edmonton Oilers | 3 | 1 | 1 | 2 | 0 | 4 | 25.0% | 4 |
| 2020-21 | NHL | Edmonton Oilers | 2 | 0 | 0 | 0 | 0 | 3 | 0.0% | 0 |
| 2022-23 | NL | Bern | 5 | 1 | 2 | 3 | 2 | - | - | 6 |
| NHL Totals | – | 24 | 4 | 8 | 12 | 5 | 50 | 8.0% | 10 | |
| Juniors Totals | – | 45 | 16 | 19 | 35 | -2 | - | - | 22 | |
| Season | Opponent | Date | G | A | P | +/- | PIM | PPG | SHG | S | Shifts | TOI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular | vs DET | Apr 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 7:23 |
| Regular | @ DET | Apr 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 16 | 12:39 |
| Regular | vs FLA | Mar 26 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 14 | 12:20 |
| Regular | @ WPG | Mar 24 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 15 | 10:44 |
| Regular | @ NYI | Mar 22 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 14 | 10:55 |