
| 2001-02 | WBAAA | Winnipeg Monarchs Bantam AAA | 26 | 10 | 11 | 21 | - | - | - | 61 |
| 2003-04 | CAHS | St. John's Ravenscourt | 19 | 20 | 12 | 32 | 0 | - | - | 82 |
| 2004-05 | WHL | Brandon | 64 | 7 | 9 | 16 | -5 | - | - | 79 |
| 2005-06 | WHL | Brandon | 68 | 14 | 14 | 28 | -3 | - | - | 91 |
| 2006-07 | WHL | Brandon | 69 | 15 | 20 | 35 | 11 | - | - | 76 |
| 2007-08 | AHL | Peoria | 31 | 4 | 3 | 7 | 5 | - | - | 46 |
| 2007-08 | ECHL | Alaska | 9 | 2 | 0 | 2 | 6 | - | - | 42 |
| 2008-09 | AHL | Peoria | 57 | 8 | 9 | 17 | 9 | - | - | 130 |
| 2009-10 | AHL | Peoria | 76 | 4 | 7 | 11 | -16 | - | - | 167 |
| 2010-11 | NHL | St. Louis Blues | 28 | 2 | 2 | 4 | -1 | 16 | 12.5% | 78 |
| 2010-11 | AHL | Peoria | 50 | 4 | 6 | 10 | -3 | 56 | 7.1% | 146 |
| 2011-12 | NHL | St. Louis Blues | 60 | 3 | 1 | 4 | 0 | 32 | 9.4% | 124 |
| 2012-13 | NHL | St. Louis Blues | 43 | 4 | 2 | 6 | 3 | 24 | 16.7% | 79 |
| 2012-13 | ECHL | Orlando | 13 | 6 | 3 | 9 | -1 | 20 | 30.0% | 34 |
| 2013-14 | NHL | St. Louis Blues | 63 | 2 | 6 | 8 | -1 | 25 | 8.0% | 126 |
| 2014-15 | NHL | St. Louis Blues | 81 | 6 | 6 | 12 | -3 | 55 | 10.9% | 116 |
| 2015-16 | NHL | St. Louis Blues | 64 | 3 | 1 | 4 | -6 | 31 | 9.7% | 68 |
| 2016-17 | NHL | St. Louis Blues | 80 | 7 | 6 | 13 | 4 | 58 | 12.1% | 104 |
| 2017-18 | NHL | Pittsburgh Penguins | 58 | 4 | 4 | 8 | -9 | 34 | 11.8% | 84 |
| 2017-18 | NHL | Vegas Golden Knights | 21 | 0 | 2 | 2 | 2 | 8 | 0.0% | 10 |
| 2018-19 | NHL | Vegas Golden Knights | 80 | 9 | 11 | 20 | 1 | 95 | 9.5% | 74 |
| 2019-20 | NHL | Vegas Golden Knights | 71 | 8 | 7 | 15 | -5 | 61 | 13.1% | 47 |
| 2020-21 | NHL | Vegas Golden Knights | 37 | 1 | 4 | 5 | 0 | 26 | 3.8% | 27 |
| 2021-22 | NHL | New York Rangers | 69 | 5 | 8 | 13 | -13 | 44 | 11.4% | 43 |
| 2022-23 | NHL | New York Rangers | 12 | 0 | 0 | 0 | -5 | 3 | 0.0% | 12 |
| 2022-23 | NHL | Minnesota Wild | 61 | 5 | 10 | 15 | -1 | 45 | 11.1% | 31 |
| 2023-24 | NHL | Toronto Maple Leafs | 49 | 4 | 2 | 6 | -13 | 26 | 15.4% | 49 |
| 2024-25 | NHL | Toronto Maple Leafs | 35 | 0 | 2 | 2 | -2 | 14 | 0.0% | 28 |
| 2024-25 | AHL | Toronto Marlies | 3 | 1 | 0 | 1 | -1 | - | - | 0 |
| 2025-26 | NHL | San Jose Sharks | 37 | 3 | 0 | 3 | -9 | 20 | 15.0% | 30 |
| NHL Totals | – | 949 | 66 | 74 | 140 | -58 | 617 | 10.7% | 1130 | |
| AHL Totals | – | 217 | 21 | 25 | 46 | -6 | 56 | 37.5% | 489 | |
| Juniors Totals | – | 201 | 36 | 43 | 79 | 3 | - | - | 246 | |
| 2004-05 | WHL | Brandon | 23 | 2 | 4 | 6 | - | - | - | 43 |
| 2005-06 | WHL | Brandon | 6 | 0 | 1 | 1 | -1 | - | - | 8 |
| 2006-07 | WHL | Brandon | 11 | 1 | 4 | 5 | -4 | - | - | 19 |
| 2007-08 | ECHL | Alaska | 2 | 0 | 0 | 0 | - | - | - | 22 |
| 2008-09 | AHL | Peoria | 4 | 0 | 0 | 0 | 0 | - | - | 2 |
| 2011-12 | NHL | St. Louis Blues | 2 | 0 | 0 | 0 | 0 | 1 | 0.0% | 0 |
| 2012-13 | NHL | St. Louis Blues | 6 | 0 | 0 | 0 | -1 | 6 | 0.0% | 2 |
| 2013-14 | NHL | St. Louis Blues | 6 | 0 | 0 | 0 | -1 | 1 | 0.0% | 6 |
| 2014-15 | NHL | St. Louis Blues | 6 | 1 | 0 | 1 | 1 | 2 | 50.0% | 0 |
| 2015-16 | NHL | St. Louis Blues | 5 | 0 | 0 | 0 | 0 | 3 | 0.0% | 7 |
| 2016-17 | NHL | St. Louis Blues | 11 | 0 | 0 | 0 | -1 | 8 | 0.0% | 8 |
| 2017-18 | NHL | Vegas Golden Knights | 10 | 2 | 0 | 2 | 4 | 6 | 33.3% | 18 |
| 2018-19 | NHL | Vegas Golden Knights | 7 | 0 | 0 | 0 | -1 | 8 | 0.0% | 17 |
| 2019-20 | NHL | Vegas Golden Knights | 19 | 0 | 4 | 4 | 2 | 9 | 0.0% | 14 |
| 2020-21 | NHL | Vegas Golden Knights | 12 | 0 | 1 | 1 | 1 | 3 | 0.0% | 16 |
| 2021-22 | NHL | New York Rangers | 18 | 0 | 0 | 0 | -1 | 13 | 0.0% | 12 |
| 2022-23 | NHL | Minnesota Wild | 6 | 0 | 0 | 0 | -1 | 2 | 0.0% | 14 |
| 2023-24 | NHL | Toronto Maple Leafs | 5 | 0 | 1 | 1 | -1 | 2 | 0.0% | 2 |
| NHL Totals | – | 113 | 3 | 6 | 9 | 1 | 64 | 4.7% | 116 | |
| AHL Totals | – | 4 | 0 | 0 | 0 | 0 | - | - | 2 | |
| Juniors Totals | – | 40 | 3 | 9 | 12 | -5 | - | - | 70 | |
| Season | Opponent | Date | G | A | P | +/- | PIM | PPG | SHG | S | Shifts | TOI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular | @ LAK | Jan 7 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 10 | 7:54 |
| Regular | vs CBJ | Jan 6 | 0 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 14 | 8:07 |
| Regular | vs TBL | Jan 3 | 0 | 0 | 0 | -2 | 4 | 0 | 0 | 0 | 12 | 9:15 |
| Regular | vs MIN | Dec 31 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 2 | 13 | 11:25 |
| Regular | @ ANA | Dec 29 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 13 | 8:55 |