
| 2003-04 | GTBHL | Toronto Marlboros Bantam AAA | 90 | 95 | 92 | 187 | 0 | - | - | 76 |
| 2004-05 | GTHL | Tor. Marlboros | 72 | 91 | 67 | 158 | - | - | - | - |
| 2004-05 | OPJHL | Milton | 20 | 13 | 15 | 28 | - | - | - | 10 |
| 2005-06 | OHL | Oshawa | 65 | 45 | 32 | 77 | -13 | - | - | 72 |
| 2006-07 | OHL | Oshawa | 67 | 72 | 62 | 134 | 25 | - | - | 60 |
| 2007-08 | OHL | Oshawa | 59 | 40 | 78 | 118 | 22 | - | - | 69 |
| 2008-09 | OHL | Oshawa | 32 | 26 | 28 | 54 | 5 | - | - | 32 |
| 2008-09 | OHL | London | 24 | 32 | 18 | 50 | 5 | - | - | 22 |
| 2009-10 | NHL | New York Islanders | 82 | 24 | 30 | 54 | -15 | 186 | 12.9% | 22 |
| 2010-11 | NHL | New York Islanders | 79 | 29 | 38 | 67 | -16 | 243 | 11.9% | 53 |
| 2011-12 | NHL | New York Islanders | 82 | 31 | 50 | 81 | -6 | 286 | 10.8% | 26 |
| 2012-13 | NHL | New York Islanders | 48 | 28 | 19 | 47 | -2 | 162 | 17.3% | 18 |
| 2012-13 | Swiss | Bern | 28 | 17 | 25 | 42 | - | - | - | 28 |
| 2013-14 | NHL | New York Islanders | 59 | 24 | 42 | 66 | -6 | 188 | 12.8% | 40 |
| 2014-15 | NHL | New York Islanders | 82 | 38 | 48 | 86 | 5 | 278 | 13.7% | 46 |
| 2015-16 | NHL | New York Islanders | 78 | 33 | 37 | 70 | 6 | 250 | 13.2% | 38 |
| 2016-17 | NHL | New York Islanders | 77 | 28 | 38 | 66 | 4 | 260 | 10.8% | 38 |
| 2017-18 | NHL | New York Islanders | 82 | 37 | 47 | 84 | -12 | 257 | 14.4% | 26 |
| 2018-19 | NHL | Toronto Maple Leafs | 82 | 47 | 41 | 88 | 19 | 286 | 16.4% | 34 |
| 2019-20 | NHL | Toronto Maple Leafs | 63 | 26 | 34 | 60 | -7 | 197 | 13.2% | 24 |
| 2020-21 | NHL | Toronto Maple Leafs | 56 | 19 | 31 | 50 | 12 | 163 | 11.7% | 14 |
| 2021-22 | NHL | Toronto Maple Leafs | 79 | 27 | 49 | 76 | -8 | 237 | 11.4% | 32 |
| 2022-23 | NHL | Toronto Maple Leafs | 80 | 36 | 44 | 80 | -7 | 277 | 13.0% | 34 |
| 2023-24 | NHL | Toronto Maple Leafs | 80 | 29 | 36 | 65 | 2 | 279 | 10.4% | 30 |
| 2024-25 | NHL | Toronto Maple Leafs | 75 | 38 | 36 | 74 | 10 | 200 | 19.0% | 46 |
| 2025-26 | NHL | Toronto Maple Leafs | 43 | 15 | 24 | 39 | -4 | 109 | 13.8% | 20 |
| NHL Totals | – | 1227 | 509 | 644 | 1153 | -25 | 3858 | 13.2% | 541 | |
| Juniors Totals | – | 247 | 215 | 218 | 433 | 44 | - | - | 255 | |
| 2006-07 | OHL | Oshawa | 9 | 7 | 12 | 19 | -4 | - | - | 6 |
| 2007-08 | OHL | Oshawa | 15 | 3 | 13 | 16 | 3 | - | - | 20 |
| 2008-09 | OHL | London | 14 | 10 | 11 | 21 | -2 | - | - | 8 |
| 2012-13 | NHL | New York Islanders | 6 | 3 | 2 | 5 | -4 | 21 | 14.3% | 4 |
| 2014-15 | NHL | New York Islanders | 7 | 2 | 4 | 6 | 2 | 18 | 11.1% | 2 |
| 2015-16 | NHL | New York Islanders | 11 | 6 | 5 | 11 | -3 | 40 | 15.0% | 6 |
| 2018-19 | NHL | Toronto Maple Leafs | 7 | 2 | 3 | 5 | -5 | 21 | 9.5% | 0 |
| 2019-20 | NHL | Toronto Maple Leafs | 5 | 2 | 1 | 3 | -3 | 24 | 8.3% | 0 |
| 2020-21 | NHL | Toronto Maple Leafs | 1 | 0 | 0 | 0 | 0 | 0 | 0.0% | 0 |
| 2021-22 | NHL | Toronto Maple Leafs | 7 | 3 | 3 | 6 | 0 | 14 | 21.4% | 2 |
| 2022-23 | NHL | Toronto Maple Leafs | 11 | 4 | 4 | 8 | -1 | 44 | 9.1% | 4 |
| 2023-24 | NHL | Toronto Maple Leafs | 7 | 1 | 1 | 2 | 0 | 22 | 4.5% | 2 |
| 2024-25 | NHL | Toronto Maple Leafs | 13 | 5 | 2 | 7 | -6 | 40 | 12.5% | 10 |
| NHL Totals | – | 75 | 28 | 25 | 53 | -20 | 244 | 11.5% | 30 | |
| Juniors Totals | – | 38 | 20 | 36 | 56 | -3 | - | - | 34 | |
| Season | Opponent | Date | G | A | P | +/- | PIM | PPG | SHG | S | Shifts | TOI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular | @ PHI | Jan 8 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 21 | 17:54 |
| Regular | vs FLA | Jan 6 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 2 | 19 | 14:57 |
| Regular | @ NYI | Jan 3 | 0 | 0 | 0 | -2 | 2 | 0 | 0 | 1 | 24 | 17:04 |
| Regular | vs WPG | Jan 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 19 | 16:02 |
| Regular | vs NJD | Dec 30 | 0 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 23 | 19:35 |