
| 2008-09 | High-WI | Eau Claire Mem. | 23 | 2 | 20 | 22 | - | - | - | 16 |
| 2008-09 | UMHSEL | Team Wisconsin | 22 | 3 | 7 | 10 | - | - | - | - |
| 2009-10 | USHL | USNTDP | 35 | 0 | 5 | 5 | -10 | 24 | 0.0% | 34 |
| 2009-10 | U-17 | USNTDP | 16 | 0 | 3 | 3 | - | - | - | 16 |
| 2009-10 | U-18 | USNTDP | 1 | 0 | 0 | 0 | - | - | - | 2 |
| 2010-11 | USHL | USNTDP | 19 | 2 | 4 | 6 | 6 | 9 | 22.2% | 4 |
| 2010-11 | U-18 | USNTDP | 27 | 2 | 8 | 10 | - | - | - | 10 |
| 2011-12 | WCHA | U. of Wisconsin | 26 | 3 | 9 | 12 | - | - | - | 12 |
| 2012-13 | WCHA | U. of Wisconsin | 38 | 3 | 18 | 21 | - | - | - | 50 |
| 2013-14 | NHL | Buffalo Sabres | 7 | 0 | 1 | 1 | -3 | 1 | 0.0% | 15 |
| 2013-14 | Big Ten | U. of Wisconsin | 36 | 8 | 17 | 25 | - | - | - | 53 |
| 2014-15 | NHL | Buffalo Sabres | 2 | 0 | 0 | 0 | 0 | 2 | 0.0% | 0 |
| 2014-15 | AHL | Rochester | 57 | 5 | 24 | 29 | -3 | 83 | 6.0% | 50 |
| 2015-16 | NHL | Buffalo Sabres | 77 | 4 | 10 | 14 | 6 | 62 | 6.5% | 51 |
| 2015-16 | AHL | Rochester | 1 | 0 | 0 | 0 | 0 | 0 | 0.0% | 0 |
| 2016-17 | NHL | Buffalo Sabres | 76 | 3 | 17 | 20 | -7 | 79 | 3.8% | 26 |
| 2017-18 | NHL | Buffalo Sabres | 53 | 3 | 9 | 12 | -11 | 53 | 5.7% | 26 |
| 2018-19 | NHL | Buffalo Sabres | 59 | 4 | 10 | 14 | -4 | 64 | 6.3% | 35 |
| 2019-20 | NHL | Buffalo Sabres | 66 | 3 | 10 | 13 | -11 | 75 | 4.0% | 41 |
| 2020-21 | NHL | Buffalo Sabres | 13 | 1 | 2 | 3 | 2 | 15 | 6.7% | 9 |
| 2021-22 | NHL | Chicago Blackhawks | 75 | 4 | 18 | 22 | -27 | 80 | 5.0% | 33 |
| 2022-23 | NHL | Chicago Blackhawks | 55 | 2 | 18 | 20 | 7 | 67 | 3.0% | 27 |
| 2022-23 | NHL | Toronto Maple Leafs | 21 | 1 | 4 | 5 | 12 | 29 | 3.4% | 29 |
| 2023-24 | NHL | Toronto Maple Leafs | 73 | 8 | 20 | 28 | 20 | 73 | 11.0% | 56 |
| 2024-25 | NHL | Toronto Maple Leafs | 66 | 2 | 21 | 23 | 23 | 74 | 2.7% | 40 |
| 2025-26 | NHL | Toronto Maple Leafs | 41 | 3 | 13 | 16 | 26 | 28 | 10.7% | 25 |
| NHL Totals | – | 684 | 38 | 153 | 191 | 33 | 702 | 5.4% | 413 | |
| AHL Totals | – | 58 | 5 | 24 | 29 | -3 | 83 | 6.0% | 50 | |
| Juniors Totals | – | 54 | 2 | 9 | 11 | -4 | 33 | 6.1% | 38 | |
| 2022-23 | NHL | Toronto Maple Leafs | 11 | 0 | 2 | 2 | -7 | 16 | 0.0% | 10 |
| 2023-24 | NHL | Toronto Maple Leafs | 7 | 1 | 0 | 1 | 0 | 5 | 20.0% | 4 |
| 2024-25 | NHL | Toronto Maple Leafs | 13 | 0 | 4 | 4 | -1 | 10 | 0.0% | 2 |
| NHL Totals | – | 31 | 1 | 6 | 7 | -8 | 31 | 3.2% | 16 | |
| Season | Opponent | Date | G | A | P | +/- | PIM | PPG | SHG | S | Shifts | TOI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular | @ NYI | Jan 3 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 29 | 18:07 |
| Regular | vs WPG | Jan 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 32 | 24:50 |
| Regular | vs NJD | Dec 30 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 30 | 23:46 |
| Regular | @ DET | Dec 28 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 32 | 22:48 |
| Regular | vs OTT | Dec 27 | 0 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 33 | 22:14 |